The main female hormones are considered estrogen, and to use this word in the singular is wrong. We can say that they make a woman, her attractiveness, height, weight, smoothness and youthfulness of the skin, hair opacity, female figure, voice, mood and sexual activity depend on them. With the slightest deviations the body reacts instantly, changing the appearance and internal state of the woman.
Hormones, there are about 30 species, but the most important for the body are 3:
If you imagine the ratio of the level of estrogen in women, the hormones will be located in the following order: E1: E2: E3 = 1: 100: 7. The most active is estradiol.
Who is in charge?
Estrogen production occurs in the ovarian follicles, and a small percentage of them are produced in the liver. The regulation of their synthesis occurs due to the hormone FSH in the pituitary gland, which stimulates the follicles.
With the onset of menopause, the work of the ovaries stops, and in this case, the estrogens produce fatty tissue. But they are wrong, and there is no use for them.
There is no separate estrogen hormone. They have a generally general formula, but they affect the body differently. Their bioactivity is as follows: 7: 100: 1. The main and most significant in the triad is estradiol. It is determined in blood tests. It is he who provides all the external attractiveness of women of reproductive age.
To read hormonal information of the ovaries, nature has created estrogen receptors. Thanks to their work, the organs perceive the information and submit to it.
Receptors are present almost everywhere, because estrogens determine the work of the whole organism: in the brain, lungs, vascular system, myocytes, osteocytes, intestines and bladder, liver and myocardium, uterus and its appendages, vagina, mammary glands, dermis and even in the eyes . They differ in quantity in different systems, therefore the clinic of estrogen disorders is so diverse and complex.
E1 - "bad" estrogen
He dominates menopause. It can be synthesized by adipose tissue, even if the reproductive system is not fully working. In the ovaries before menopause, the body uses it to create estradiol.
In menopause, this process is dramatically reduced. In women with increased weight, it provokes the development of oncology of the breast and cervix between the ages of 30 and 40 years.
The main functions include:
- Active participation in the formation of figures for the female type.
- Direct effect on the formation of secondary sexual characteristics.
- Affects the pigmentation processes of the genitals and areoles.
- Responsible for sexual desire.
- Stimulates bone growth.
- Participates in the growth and maturation of follicles in the ovaries and ovulation.
- Contributes to the growth of the uterus and the creation of a network of vessels for the development of the fetus upon the occurrence of pregnancy.
- Increases blood clotting during menstruation and childbirth.
- Promotes the development of edema by retaining sodium in the body.
- Affects the mood of pregnant women.
Estrogens and the female body
The level of hormones throughout life is constantly fluctuating.
- regulates all sexual function completely,
- ensures the normal flow of the MC,
- always increases during puberty, during pregnancy (outside of these periods it is in balance with another female hormone, progesterone),
- ensures the development of secondary sexual characteristics,
- protects vessels from atherosclerosis,
- regulates the state of the blood vessels, adjusts in the right mode the operation of all cells,
- regulates the metabolism, not allowing obesity to develop,
- affects bones and subcutaneous tissue,
- prevents the increased activity of the sebaceous glands.
Under the influence of some unfavorable moments, it begins to be produced not only in the ovaries, but also in the liver, skin cells, muscles, adrenal glands, and even in the brain. Doctors call this high estrogen level in women with a predominance of progesterone estrogen dominance.
What are the reasons for the increase?
After 35 years of age, increased estrogen occurs in every other woman. There are 3 main factors causing such dominance:
- Estrogen receptor hyperactivity - this can occur when they are stimulated by certain estrogen-like substances. These include phytoestrogens and xenoestrogens.
- Excessive production of these hormones inside the body.
- Low levels of progesterone in the body.
Etiology of increased estrogen production
Excess estrogen is not uncommon. It can also increase due to the excessive receipt of it from outside. This happens with improper nutrition, the supply of endocrine disrupters, the use of products with GMOs, high pesticides, products with phytoestrogens.
Among the reasons for the increase in estrogen include:
- early puberty (about 7 years old)
- reception ok
- prolonged stress
- smoking and alcohol
- deficiency of vitamins and minerals
- hypo-and hyperdynamics,
- endocrinopathy and obesity.
Other reasons for the increase
In some cases, the causes and symptoms of excess estrogen in women are caused by a combination of several factors. Weight gain of even 5-7 kg increases the level of estrogen by converting androgens into them. This occurs through aromatization, this process is only necessary in menopause, when the body thus tries to maintain the estrogen content in the body.
This transformation creates a vicious circle in the body of a lady: weight gain leads to an increase in androgens, which subsequently increases the amount of estrogen. The latter, in turn, leads to weight gain, etc.
Losing weight in such cases is not easy, because excess estrogen affects other hormones, such as leptin and thyroxin, which cause sustained weight gain.
It is also important exposure to xenoestrogens. These are chemicals that are contained in food products, cosmetics, household chemicals. They mimic estrogen and interact with estrogen receptors.
When inhaled, harmful vapors increase the level of the hormone in the blood. These toxins also gain weight.
Hypothyroidism can affect estrogen levels. Thyroid hormones help maintain a balance of progesterone and estrogen. With hypothyroidism, progesterone decreases, and estrogen begins to grow.
It is clear that the causes of increased estrogen in women and the symptoms of the disease are closely interrelated.
Manifestation of increased estrogen
Symptoms of enhancement are as follows:
- Sudden uncontrolled weight gain. It occurs even with the most rational diet or diet, physical activity. This is one of the main signs of increased estrogen in women. Such a woman can lose weight only when leveling hormonal levels.
- Violation of MC In 80% of cases, the hormone failure, or rather the signs of an increased level of estrogen in a woman, becomes to blame. That is why, if the regularity of the cycle is broken, the periods have become too abundant, be sure to check out the hormones.
- Hypersensitivity of the mammary glands, their swelling. These are also signs of increased estrogen in women. If the breast became rounded without objective reasons, estrogen dominance can be suspected.
- Pain in the mammary glands. If it is marked against the background of low progesterone levels in women, this is a clear sign of elevated estrogen. The condition is very negative for the mammary glands, because they not only suddenly increase, pain arises at rest (on the sides of the chest and on top) or may be acute at the slightest touch of the chest. These are symptoms of an excess of female hormones.
- Increased emotionality. Often, during menstruation, a woman becomes too nervous, tearful, and irritable. These are symptoms of excess female hormones estrogen. This state becomes constant with the dominance of the hormone.
- Frequent headaches. Despite the hundreds of causes of headache, if they become permanent - these are signs of increased estrogen in a woman. It is likely that with this progesterone will be low.
- Abundant hair loss. This is one of the signs and symptoms of increased estrogen levels in women. Although it is believed that baldness 2 times more threatens men, but the girl also risks losing the pomp of her hair in her prime. She will not be bald, of course, but her hair will become sparse.
- Memory impairment is another sign of hormonal imbalance. A woman begins to forget important dates, keys, handbag, etc. It is possible that all this effect of excess estrogen in women.
- Insomnia. It is associated with the fact that elevated estrogen blocks the production of melatonin (sleep hormone). And if progesterone (the hormone of calm) is also lowered, you will definitely not sleep at night.
- Signs of increased estrogen in women include the emerging manner of not stopping in conversation, work, playing sports, etc. The woman simply does not succeed.
- Exhaustion of the body - constant lack of sleep leads to exhaustion and accumulation of all the problems associated with this.
Increased hormone levels always mean danger. An overabundance of estrogen in women can cause a malfunction of the thyroid gland, leading to weight gain and osteoporosis.
Prolonged estrogen dominance causes:
- increase in blood pressure,
- breast cancer,
- uterine tumors
- increased blood clotting and blood clots,
- leg cramps,
- violations of MC,
- disorders of the central nervous system and psyche.
Principles of treatment
For successful treatment should establish the cause of imbalance. If the aromatization process is increased, zinc, selenium, aromatase inhibitors, and vitamin C are prescribed.
For treatment, they take the drugs Arimidex, Aromasin, Fazlodeks, Tamoxifen, Clomiphen, Femara, Mastodinon and other herbal products, all of which reduce estrogen.
Also reduces blood estradiol "Zoladex", "Lupron", "Goserelin", etc. Some women are afraid to take hormones, but their proper selection will not give side effects. But the rejection of HRT will lead to complications.
In special cases, surgery is necessary: removal of the ovaries or their irradiation in the event that a woman has menopause.
Proper diet - the first step to recovery. The use of organic (natural) products is recommended: more cruciferous (different types of cabbage, radish, radishes), up to 30 g of fiber per day. Foods rich in fiber (fruits, vegetables, legumes, seeds, whole grains), remove excess fat and cholesterol and reduce estrogen.
Some of them can increase metabolism or reduce the symptoms of elevated estrogen. Such compounds include DIM, maca root, zinc, calcium-D-glucarate, and ashwagandha.
Prevention, or How to return estrogen levels back to normal
Prevention measures are as follows:
- Limit alcohol intake - it disrupts the liver, and the entire metabolism of estrogen occurs here.
- Eat organic foods.
- Eat more fiber.
- Eat foods with probiotics - these include dairy products and kvass, sauerkraut, pickles, kimchi and tofu. You can take and probiotic supplements.
- Follow a balanced diet with plenty of vitamins (B).6, C, E, D, etc.) and minerals (zinc, selenium and magnesium). A lot of vitamin B6 found in beef liver, sea fish, nuts and beans, zinc - in pork and lamb, buckwheat and oatmeal, and magnesium - in almonds, sea kale, peas and barley groats.
- Take rosemary essential oil - it is a powerful antioxidant, normalizes estrogen levels, immunity and thyroid. Fights signs of elevated estradiol.
- Avoid exposure to xenoestrogens by limiting contact with them.
- Control stress. It suppresses progesterone and increases estrogen.
An increase in estrogen can talk about various diseases, which will help to identify the correct diagnosis. To delay the treatment is not worth it, because the more neglected pathology, the more difficult it is treatment.
Estrogens and their role in the body
Estrogens are formed mainly in the ovaries. Partially, these hormones are produced in the adrenal glands, liver, brain. Sex hormones in women are also produced by adipose tissue. It is particularly active in the production of estrogens if, for some reason, the ovaries no longer cope with their hormone-forming role. This explains why women often grow stout in case of hormonal imbalance. In this way, the body reacts to stress that occurs when diseases of the organs of the reproductive system, age-related changes in the composition of hormones.
There are different types of estrogen hormones. Among them are the 3 most active: estradiol, estrone and estriol.
Estradiol is most active during the reproductive period of a woman’s life. He is involved in the formation of protein tissue necessary for the development of genital organs. The content of the hormone in the body affects the work of the nervous, cardiovascular and all its other systems.
Estron is produced in smaller quantities, but it is he who is responsible for the appearance of secondary female sexual characteristics, the state of the uterus, its readiness to bear the fetus during pregnancy. The rate of aging of an organism depends on the content of the hormone estrogen in the period of postmenopause.
Estriol is called the pregnancy hormone, as it is produced by the placenta, is responsible for the normal development of the fetus.
The importance of the role that these hormones play in the body does not mean that the more estrogen it produces, the better. For each female body there is its own individual norm of estrogen content, in which the woman’s health, appearance and physical activity correspond to her age and physiological state. The level of estrogen begins to grow at the time of the onset of sexual development, reaches a maximum at about 30 years of age, and then begins to gradually decline due to a weakening of the fertility function. An excess of estrogen hormones in the body is a pathology.
What is dangerous excess estrogen
Excess estrogen indicates abnormal work of the organs by which they are produced, hormonal failure. The close relationship of hormonal processes with all the others immediately leads to serious problems with the general state of health, affecting the appearance of a woman.
The consequences of excessive production in the body of female sex hormones are:
- the formation of hormone-dependent tumors of the genital organs (benign - fibroids, cancer of the uterus, ovaries), endometriosis, and also such diseases of the mammary glands as mastopathy, fibroadenoma and cancer,
- metabolic disorders, endocrine system organs,
- formation in the body of a deficiency of nutrients, deterioration of the woman’s appearance due to poor hair condition, brittle nails, dry skin, changes in shape,
- failures of the menstrual cycle
- decrease in sexual desire,
- headaches, pathological changes in bone tissue, condition of mucous membranes.
Symptoms of excess estrogen
Signs are the occurrence of chronic inflammatory diseases of the external female genital organs (colpitis, vulvovaginitis), mental instability, exacerbation of diseases of the gastrointestinal tract, thyroid and pancreas.
Symptoms of an excess of female sex hormones in the body are:
- irregular onset of menses, alternation of scanty and heavy menstruation,
- inability to get pregnant,
- swelling and pain in the mammary glands due to the occurrence of edema due to impaired water-salt metabolism,
- an increase in the abdomen due to fluid retention in the tissues,
- increased appetite, which in turn leads to an increase in body weight,
- disorders of the nervous system (depression, irritability, insomnia, headache),
- loss of attention and memory
- feeling tired all the time
- decrease in sexual activity
- vaginal dryness (disruption of the cervical glands that produce mucus). In this regard, women suffering from hyperestrogenic, often have infectious and inflammatory diseases of the uterus and appendages.
During pregnancy, there is a significant increase in the content of estrogen in the blood, since the placenta begins to produce them additionally, and they are also formed in the liver of the fetus. It is the increased estrogen levels that explain the woman’s nausea and vomiting (toxicosis) during this period.
The cause of failure is a malfunction of the pituitary gland. The production of estrogen in the ovaries occurs under the influence of hormones such as FSH, which stimulates the maturation of follicles, and LH, a luteinizing hormone necessary for the formation of the corpus luteum.Excessive intake of female hormones leads to disruption of the processes associated with the phases of the menstrual cycle. In this situation, the excess of FSH in the first phase leads to the absence of ovulation, an abnormal increase in the dominant follicle, the formation of follicular cysts.
With a lack of LH in the second phase of the cycle, there is a deficiency of the corpus luteum and a decrease in the production of progesterone - the sex hormone, which contributes to the preservation of the fertilized egg and the development of pregnancy. In this case, in an excess amount of estrone is formed, which leads to the impossibility of its preservation.
Diseases of the thyroid and other endocrine glands can also be the cause of the symptoms of endocrine disorders.
It can occur under the influence of genetic factors or as a result of congenital or acquired disorders of the endocrine system. In this case, the girl prematurely appears external sex characteristics, begin monthly. The physically weakened body cannot cope with the additional load, as a result of which a hormonal failure occurs.
Treatment or long-term contraception with hormonal drugs
Often women are forced to resort to hormone replacement therapy to eliminate menstrual disorders. Contraceptives are used to suppress ovulation by increasing the level of estrogen in the bloodstream, intrauterine devices. If the funds are chosen correctly, they cause hormonal imbalance.
Symptoms of excess estrogen appear in women of menopausal age, if they use hormonal drugs to relieve such illnesses as hot flashes, osteoporosis, and neuropsychiatric disorders.
Eating genetically modified foods
The purpose of growing plants and animals with an improved genome is to accelerate their growth, develop resistance to harmful environmental conditions. However, a change in the gene structure leads to impaired hormone levels. By consuming the meat of animals raised in this way, fish, and plants, a person risks getting serious health problems.
Beriberi, fasting, unhealthy diet
Lack of folic acid, selenium and other nutrients in the body leads to disruption of the formation of enzymes necessary for the implementation of processes in which estrogens are consumed. As a result of beriberi, an excess of hormones is formed.
Abuse of plant foods and drinks containing phytoestrogens (legumes, soybeans, beer, coffee), the use of fatty meats also contribute to the accumulation of estrogen in the body.
How to lower the level of estrogen
To eliminate the symptoms that indicate the formation of excess estrogen in the body, doctors, first of all, recommend women to change their lifestyle and adjust their diet. In order to prevent hyperestrogenism, it is recommended that women use hormonal therapy or contraception to use new-generation drugs that balance the levels of estrogen and progesterones, which reduce their level.
If necessary, women are given medication therapy. Estrogen reductions are achieved with the help of drugs of various groups. Some of them block the production of estrogen in the ovaries. These include clomiphene, tamoxifen.
Estrogens are formed in the body of a woman from androgens by exposing them to a special enzyme, aromatase. Therefore, to reduce the level of estrogen used and another group of drugs that reduce the production of this enzyme (anastrozole, letrozole, exemestane).
The role of estrogen
Estrogen in women already in the prenatal period lays the formation of female genital organs. At the stage of reaching girls of puberty, the hormone is necessary for their development. There are three types of female hormones. The hormone estradiol is the main one. As a rule, it is called estrogen. There is estrion and estrone. They are similar in function, but vary in quantity and activity. Estrogen is produced in the ovaries, adrenal glands, and some other organs.
The role of estrogen in a woman's body is invaluable. He participates in many important processes:
- cell renewal
- improvement of blood vessels,
- normalization of metabolic processes in the body,
- development of genital organs
- normalization of the menstrual cycle
- healthy pregnancy course.
It has an impact on the nervous system and the appearance of a woman.
At a normal hormonal level, a woman looks good, has no diseases in the genital area, has healthy sexuality, is capable of childbirth.
Causes of hormonal imbalance
Hyperestrogenism is a condition of the body in which the amount of estrogen produced is increased. If the level of sex hormones is elevated, women develop various diseases:
- endometrial polyps and cancer,
- tumors of various etiologies in the breast and uterus,
- cervical dysplasia,
- pancreatic diseases,
- vascular diseases,
- predisposition to thickening of the blood.
The causes of the symptom of excess female hormone estrogen can be external and internal factors. The ingestion of estrogen from the external environment happens when using:
- plastic bottles
- Shrovetide-based cosmetics
- dairy and animal products,
- when drinking coffee.
High hormones can develop under the influence of many internal causes:
- excess weight,
- early puberty
- endocrine disorders (hyperthyroidism, diabetes),
- smoking, alcohol,
- lack of necessary vitamins,
- excessive exercise,
- hormonal contraception,
- stressful conditions
- sedentary lifestyle.
Symptoms of increased hormonal levels in women
With an excess of estrogen in women, the symptoms are varied. They can be divided into two types - physiological and psychological. When hormone levels are elevated, symptoms of a physiological nature are observed:
- menstruation becomes profuse and painful
- frequent headaches,
- blood pressure rises
- there is a rapid weight gain
- the blood sugar level goes down,
- there are problems with the gallbladder,
- nausea periodically occurs
- trouble sleeping
- freezing limbs
- roars in the ears,
- heaviness appears in the legs
- more than usual hair fall out
- appearance becomes unhealthy.
And also the woman has to deal with psychological manifestations of high hormonal levels, which manifest themselves:
- panic attacks,
- memory lapses
- mood swings,
- decreased libido.
During menopause, an increase in hormonal levels is accompanied by such unpleasant symptoms as sweating, hot flashes, fatigue, and nervousness.
Treatment of hyperestrogenia
Having noticed the first symptoms, it is necessary to consult a doctor. Prolonged non-treatment of hyperestrogenia leads to complications in the form of:
- thyroid disease,
- malignant tumors in the chest and uterus.
Hyperestrogenism affects the thyroid gland, endocrine glands become inflamed. Violation of the adrenal glands leads to a breakdown, low blood pressure, muscle atrophy. An imbalance of hormones in the genitals causes menstruation disorders in women.
To determine the level of estrogen, a number of special tests are assigned:
- special blood test for hormones
- Ultrasound of the pelvic organs,
- endometrial histology,
- calculating the karyopicnotic index,
- functional diagnosis of the ovaries - a symptom of "pupil",
- cytological examination of vaginal smear to assess ovarian function.
If the tests show that estrogen levels are elevated, therapies will be aimed at identifying the causes of their excess amount. Then follow a series of procedures aimed at reducing their number.
Removal of hormones without harm to human health occurs according to a certain pattern. In the liver, transmutation of estrogens to other compounds occurs, which are derived when the right amount of magnesium and SAM antioxidant are available.
Further, these compounds bind to glucuronic acid so that the harm from the hormone elimination process is minimal. Special bacteria that live in the gastrointestinal tract by means of secreted enzymes destroy the connection between estrogen and acid, thereby preventing it from re-entering the bloodstream.
In order for the removal of extra hormones to give a positive final result, fiber and prebiotics must be present in the diet, which will establish healthy digestion and the body's microflora.
If hyperestrogenism is short, proceeding without comorbidities, it is enough to change the lifestyle:
- Adjust the correct diet.
- There are enough proteins. Meat and fish products, eggs, beans and other legumes contain the amino acids necessary for the normal functioning of the liver, and are their substitutes.
- Observe a special diet.
- Eat omega-3 fats - they prevent cancer.
- To establish the normal functioning of the gastrointestinal tract - the use of foods rich in fiber.
- Introduce phytoestrogens in the diet, which contribute to the withdrawal of synthetic and natural types of estrogen.
- Limit ingestion of synthetic hormones.
- Normalize body weight.
- Eliminate bad habits.
- Do physical education.
- Less nervous.
- Rest more.
Fish oil, folic acid, vitamins of group B take part in the process of processing estrogen into other compounds. Vitamin B - the main assistant in the processing of protein in the body, able to increase the protective functions of the body.
Every woman, girl should take preventive measures to control the level of estrogen. Proper use of contraception, avoidance of stressful situations, a healthy lifestyle support metabolism and protect women from hormonal disruptions.
It is vital to consult a doctor in time for any violation in the reproductive sphere. Most often, physiotherapeutic treatment is applied at the beginning of treatment, without the use of hormonal therapy, thereby reducing the risk of the harmful effects of synthetic hormones on the body.
But often women ask for help when the level of estrogen is seriously elevated and one cannot do without hormone correction. In this case, to reduce estrogen in women and ovarian activity, medication therapy is prescribed, sometimes - radiation.
Surgery must be prescribed in the case when the cause of hyperestrogenia is a benign tumor of the ovary. Before surgery, an ultrasound examination is necessary to exclude malignant tumors.
It can be concluded that the earlier and more accurately the diagnosis of the patient’s condition is carried out, the more positive the prognosis of her recovery will be.
Symptoms of disorders
A woman gives birth to children, remains balanced and calm, if she does not disrupt the hormonal balance. Any pathology, and especially an overabundance of estrogen and a decrease in progesterone, cause irritability, nervousness, a tendency to depression, problems with the functioning of internal organs. Hormones are produced in the ovaries as well as the adrenal glands.
Estrogens in large quantities are added to animal feed, today the hormone is found in groundwater, which is dangerous for any person.
The norm is a slight increase in estrogen in the first phase of the menstrual period. After the full maturation of the egg and its release from the ovary, an increase in progesterone occurs. It is possible to recognize the first signs of changes in the hormone estrogen with the help of a medical examination, in most cases the female body can cope with slight fluctuations in hormones. If the state of health deteriorates and the following signs of increased hormone appear in the body, you should definitely ask for help:
- frequent mood swings for no apparent reason
- severe pain during menstruation,
- bleeding in the middle of the menstrual cycle,
- pain in lower abdomen.
Such symptoms should worry the woman, since there are irregularities in the menstrual cycle, diseases of the internal genital organs and other health problems develop. First, you will need to donate blood for analysis, ultrasound, as well as other laboratory tests, because the reason may not only be in violation of the hormonal balance.
Changes in the menstrual cycle
Excess estrogen in women almost always affects the course of the menstrual cycle. The amount of discharge in such cases increases, menstruation becomes more prolonged. Increased hormonal substances lead to chest pain, bloating during menstruation due to excessive fluid accumulation in the tissues under the influence of excess hormone.
Often a small amount of blood appears between menstruation. Premenstrual syndrome becomes more pronounced and painful. Since an increased level of estrogen has a different effect on women, menstruation may disappear altogether or become scarce, there are problems with conceiving a child. If there is no positive result in planning a pregnancy for more than a year, the hormonal level is most likely violated.
Menopause and Estrogen Disorder
An excess of estrogen is acutely felt during menopause. Women aged 45 or 50 often take hormones to reduce the unpleasant symptoms of menopause. Acceptance of such funds in most cases reduces the level of estrogen, affects the amount of progesterone. Due to dramatic changes the skin suffers, dryness in the vagina appears.
Hormone replacement therapy in many women can cause side effects, so when menopause occurs, you cannot self-medicate and take any pills without a prescription. If during menopause increased estrogen in women, the following symptoms occur:
- excessive sweating
- mood swings
- dry vagina.
Hormone levels can often be adjusted by changing your diet and lifestyle.
Excess estrogen in women affects mood and psychological state. It often happens that suddenly changes behavior, there is a tearfulness, despondency, irritability. The female body is designed in such a way that the slightest changes in the hormonal background affect one's well-being and vital activity.
The performance decreases, memory deteriorates, and panic attacks sometimes appear. If estrogen is elevated, the sexual behavior of the weaker sex changes, libido decreases, vaginal dryness is observed. Such symptoms can be a sign of gynecological and other serious pathologies that only a doctor can identify.
Inevitable changes in the body are associated with puberty. Under the influence falls and the level of hormones in the blood of a teenager. The first menstruation, breast augmentation and other symptoms are normal for girls of a certain age, but if these signs appear before the age of 7, then the level of estrogen is very high and you cannot do without testing.
Pregnancy and lactation
A natural process is the change in the level of hormones during gestation. Estrogens increase, begins toxicosis, which can last from several months to the entire period of pregnancy. Such changes take place after childbirth and at the end of breastfeeding. Hormonal background is stabilized, and with it improves skin condition and other symptoms pass.
The presence of hormones in modern foods leads to serious violations of women's health and all internal organs. Hormones are added to feed by unscrupulous manufacturers, which causes serious harm to health. Unbalanced nutrition, lack of vitamins and minerals also leads to increased production of unnecessary estrogen. The risk factors for women also include bad habits.
Oversized work badly affects a state of health and can raise level of hormone and influence the process of their synthesis. In the same way as excessive loads, the absence of movement, activity, and sports in life is harmful.
The female body is very sensitive to various external factors that can quickly and easily increase estrogen. Reproductive health and other systems directly depends on the balance of hormones. Knowing the main symptoms, it is possible to determine in time the onset of a serious pathology and prescribe proper treatment.
The functions of estrogen in the body
Estrogens, despite the fact that these are female hormones, are present in approximately equal amounts in the body of both women and men. Their greatest amount is synthesized in the ovaries, but a certain part is also produced by the adrenal glands, liver, brain, and even adipose tissue. Estrogens are synthesized from the male hormone androgen testosterone through its interaction with the aromatase enzyme. In total there are three types of estrogen hormones:
Estradiol is the most important female hormone responsible for the synthesis of protein tissue and the formation of reproductive organs. Affects the work of the whole human body, including the cardiovascular, digestive and nervous systems, as well as other vital organs.
- Estron, on which the formation and development of secondary sexual characteristics depend, as well as the health of the uterus, its readiness for a woman to bear a child and normal growth during pregnancy. In addition, it is responsible for the aging of the body in postmenopausal women.
- Estriol is a hormone that is responsible for the normal development of the fetus during pregnancy. Produced by the placenta.
The ideal level and ratio of these hormones is considered individually for each woman on the basis of her age, lifestyle and genetics, but their amount clearly beyond the normal range is a pathology that needs treatment. However, a reduced amount of estrogen is also bad, as they perform many useful functions in the body, including:
- normal development of the reproductive system of a woman: uterus, fallopian tubes, vagina, mammary glands,
- the formation of secondary sexual characteristics,
- participation in cell repair processes
- normalization of metabolism in the body,
- bone strengthening, prevention of osteoporosis,
- improvement of blood composition due to the production of proteins and binding biological substances,
- stimulation of coagulation factor synthesis in the liver,
- prevention of atherosclerosis, lowering blood cholesterol levels,
- positive effect on vascular health,
- ensuring the health and beauty of the skin, strengthening nails and hair,
- normalization of the frequency and regularity of the menstrual cycle,
- suppression of excess activity of the sebaceous glands,
- ensuring the normal functioning of the mammary glands, suppression of lactation outside the period of breastfeeding.
Thus, it is difficult to overestimate the importance of estrogen in women: this hormone is responsible not only for their sexual health, but also for the normal operation of almost all body systems.
Because of this, it is very important to identify hormonal disorders in time and take appropriate measures.
Reasons for oversupply
Doctors can not pinpoint the cause of estrogen overload in a woman, but highlight risk factors that increase a person’s susceptibility to this pathology several times. Very often, not one acts on the body, but many such “provocateurs” of the production of female hormones, which together lead to a serious increase in their number. These include:
- bad habits such as smoking and frequent drinking of alcoholic beverages, especially beer,
- excess weight - adipose tissue synthesizes estrogens, because its significant deposits can increase their overall level,
- not active lifestyle,
long-term use of hormonal drugs for treatment or as a method of contraception,
- the use of genetically modified products, as well as the meat of animals and birds, which were grown on fodder containing estrogen-like substances,
- high content of phytoestrogens in the diet: they are present in legumes, soybeans, hops, bran, coffee, flax, oats, pumpkins, nuts, broccoli, spinach, cabbage, pomegranate, dried apricots, sunflower seeds and some spices like sage and calendula,
- poor or unhealthy diet, lack of vitamins,
- phytoestrogens, which penetrate the body through cosmetics, such as oils, shampoos, decoctions and oily-based creams,
- regular stress and excessive exercise, which can reduce testosterone levels and increase estrogen levels as a compensatory mechanism,
- use of steroid drugs
- use of plastic bottles,
- too early puberty in girls, which results in a hormonal failure due to too much stress on a weak body,
- hereditary and congenital factors
- ovarian cyst,
- benign and malignant tumors of the adrenal glands and genitals,
- neoplasms of a different nature, some of which can produce estrogen,
- endocrine diseases, disorders of the pituitary and other endocrine glands.
The cause of excess estrogen can be any external or internal factor that affects not only their quantity, but also the level of other hormones, such as testosterone and progesterone. Another reason for violations may be the wrong ratio of different types of estrogen in the body.
Impact on a woman
The symptoms of elevated estrogen levels are diverse and affect both the physiological and psychological state of the woman. Their nature and severity may differ depending on the patient's age and general health, but prolonged hyperestrogenism, which was not treated in any way, eventually will inevitably lead to serious complications and pathologies.
Symptoms of hyperestrogenism
Especially strong symptoms of excess estrogen in women occur during menstruation. In addition, it is they who explain toxicosis during pregnancy. Many women consider the unpleasant manifestations of hyperestrogenemia to be tolerant and try to treat its complications separately, because they delay in going to the doctor, not knowing what harm hormonal disorders can do to their health. Therefore, doctors advise to be examined by an endocrinologist and a gynecologist immediately. with the following symptoms:
- Disorders of the menstrual cycle. It becomes irregular, while menstruation is painful. In addition, there may be alternation of heavy and scanty menstruation or bleeding between cycles.
- Edema of the mammary glands, accompanied by coarsening and swelling, as well as pain. A sharp increase in the sensitivity of the nipples.
- Digestive disorders: increased appetite, water retention in the body, nausea and vomiting, constipation and diarrhea. Often, a woman gains weight, even with proper diet.
Periodic headaches and lower abdominal pain.
- Feeling of heaviness in the legs and constant unexplained fatigue, which leads to impaired concentration and memory impairment.
- Various disorders of the nervous system that lead to psychological problems: insomnia, sudden unexplained mood swings, excessive irritability, depressive states, apathy, panic attacks, hysteria and nervousness.
- Systematic increase or decrease in blood pressure, low blood sugar.
- Tinnitus, vertigo.
- Dullness and hair loss, brittle nails, rashes on the face. In general, the unhealthy appearance of a woman, even if she is properly caring for herself, speaks of hormonal disorders.
- Decrease in sexual activity, up to frigidity.
Effects on the body and complications
In addition to its primary symptoms, hyperestrogenism in women can lead to many complications and concomitant diseases. Violations of the adrenal glands and other endocrine glands, which are often the cause of increased levels of hormones, even worse if not treated. The most common complications associated with excess estrogen are:
- infectious diseases of the uterus and appendages associated with impaired secretion of cervical mucus,
- cardiovascular diseases such as atherosclerosis and thrombosis,
malignant tumors of the mammary glands and uterus,
- thyroid disease,
- fertility loss
- various psychological disorders.
Treatment and control of hormone levels
When diagnosing hyperestrogenism, blood tests for hormone levels, a study of a vaginal mucus smear and an ultrasound of the pelvic organs are performed. If an increased level of female hormones is confirmed, further diagnosis and therapeutic measures will be aimed at eliminating the cause of the pathology. In selecting the best drugs and the appropriate treatment regimen, the age of the woman and the presence of various diseases are taken into account.
Sometimes, with mild levels of impairment, treatment is carried out on the basis of physiotherapy, without the use of medical drugs. But most often women who need serious medical intervention go to the doctor for help. Prescription pills are selected for them in person, which help reduce the synthesis of estrogens and block or inhibit the aromatase enzyme that forms them. Such funds are divided into four types:
- Antiestrogenic. They affect the brain section of the hypothalamus, suppressing the synthesis of hormones. There are several contraindications, which include tumors of the hypothalamus, pituitary and genital organs, liver disease. Examples of such drugs are tamoxifen and clomiphene.
Antioxidants containing zinc or ascorbic acid. Slow down the work of the aromatase enzyme, preventing it from turning testosterone into estrogen.
- Aromatase inhibitors, for example, aminoglutetimid. They block aromatase, as well as antioxidants, but, in addition, they affect several other enzymes, interfering with the synthesis of other steroid hormones. Contraindications of these tablets include liver and kidney disease.
- Contraceptive drugs with low estrogen levels.
Sometimes carry out medical radiation. If an excess of hormones is caused by a benign ovarian tumor, the patient is prescribed a surgical operation.
Often, women try to lower the level of hormones by folk remedies, such as decoctions, tinctures and extracts of ginseng, aloe, blackberry, red clover, cuffs and other useful plants, but this method of treatment is ineffective and suitable only as a supplement to the main drug.
In addition to drug treatment, it is recommended to observe the prevention of violations of hormone levels. The measures to prevent it include a healthy, balanced diet, moderate exercise, avoid excessive fatigue and stress. In addition, an important role is played by the correct use of hormonal contraceptives and the selection of only qualitative means of this category.
Another important point that many women neglect is the timely visit to the doctor at the first signs of hormonal disruption. Ideally, even in the absence of symptoms, a woman should undergo regular examination by an endocrinologist at least once every six months. This will help her to start treatment in a timely manner and avoid the harmful effects of synthetic drugs.
The effect of estrogen on a woman's body
The most important hormone in a woman’s reproductive system is estrogen, because it performs the following functions:
- ensures normal growth of the uterus during pregnancy,
- serves as a kind of control of the formation of the endometrium during the menstrual cycle,
- provides a healthy course of pregnancy
- responsible for the course of the menstrual cycle within the physiological norm,
- provides a normal metabolism
- a positive effect on the condition of the skin, hair and nail plates,
- normalizes the development and functioning of the mammary glands outside of pregnancy and during breastfeeding of the child,
- prevents the development of atherosclerosis,
- prevents too active functionality of the sebaceous glands.
Judging by the above list, every woman should constantly monitor the level of estrogen, because the health of the reproductive system and the whole organism depends on it directly.
Reasons for increased estrogen
The condition in question may arise for various reasons - doctors still cannot accurately identify any specific reasons. But well-known provoking factors increase estrogen levels:
- tumors of benign and malignant nature, developing in the ovaries,
- pathological processes in the adrenal glands,
- neoplasms of a different nature, which independently produce estrogen,
- pituitary adenoma,
- ovarian cyst.
In addition, improper nutrition, irregular sexual relations, diseases of the reproductive system of the chronic form of the disease, diseases of the endocrine system and chronic nerve overstrains can increase the level of estrogen in the female body.
In many cases, the state in question provokes not one of the listed factors, but a combination of several. Therefore, a woman will have to undergo a full-fledged examination of narrow specialists - such an approach to diagnostic procedures will help to prescribe an effective treatment.
High estrogen in women: symptoms and complications
Of course, ideally, every woman should undergo preventive examinations at the gynecologist at least once every six months, during which laboratory tests of biomaterials will also be carried out. This is how a doctor will be able to detect an increase in estrogen and take timely measures to treat. But, unfortunately, in practice, women visit a gynecologist in the most extreme cases, so it will not be superfluous to know the first signs of the disease in question:
- mammary glands begin to coarse, become more dense,
- weight increases, even if a woman keeps to a diet
- occasionally pain in the lower abdomen,
- rash appears on face
- nipples on mammary glands become too sensitive
- the hair on the head falls out, becomes dull,
- blood pressure rises regularly,
- the menstrual cycle is broken,
- there are problems in the digestive system - for example, after eating nausea or vomiting may occur,
- the bowels are disturbed - a woman is worried about constipation or diarrhea
- changing sleep
- fluctuations in psycho-emotional background.
The degree of intensity of each of these symptoms is individual and depends on the woman's age, her general state of health. If a high level of estrogen is constantly present and no treatment is carried out, then the following pathological conditions can develop:
- lower extremity cramps
- thyroid disease link to previous article today,
- the formation of blood clots in the vessels
- development of mastopathy,
- development of a malignant tumor of the breast,
- absence of pregnancy
- problems with the nervous system,
- mental problems.
Treatment of high estrogen levels in women
The treatment regimen of the considered condition is selected for each patient in a strictly individual manner - everything will depend on the woman’s age, the results of laboratory and instrumental studies, the presence of diseases of the internal organs. There are, of course, general recommendations for therapy to reduce and normalize estrogen levels — for example, the following medications may be prescribed to the patient:
If a woman is in the period of menopause or menopause, then for medical reasons she may be prescribed a surgical removal of the ovaries, radiation or specific medical therapy - all these actions will be aimed at suppressing the hormonal activity of the ovaries.
If the choice of a doctor falls on specific medical drugs, then it can be:
If a decision is made to remove the ovaries, then the following types of surgery can be applied:
- oophorectomy - surgery for the classical removal of the ovaries,
- Ovarian ablation is a modern method of surgical intervention for the removal of the ovaries with a laparoscope, which is gentle.
All of these techniques, which are used to suppress the hormonal activity of the ovaries, are equally effective. Conducting such treatment prevents the development of tumors of a malignant nature in the body of a woman.
Note:With a high level of estrogen in a woman, the doctor will definitely prescribe hormonal drugs. Many patients are literally afraid of taking them, although with the right choice of a specific medication and a precisely calculated dosage, the hormonal drugs are absolutely harmless.
High estrogen levels are a dangerous condition for a woman. The fact is that in the absence of any correction, she will develop complex, severe pathologies already associated with the risk to life. Only a timely visit to the doctor will help you choose a gentle method of treating the condition in question, so you need to be extremely attentive to your own well-being and seek medical help at the first sign of dysfunction of the reproductive system.
Tsygankova Yana Alexandrovna, medical commentator, therapist of the highest qualification category
25,964 total views, 6 views today